Asset Details
Do you wish to reserve the book?
Single Nanocrown Electrodes for High‐Quality Intracellular Recording of Cardiomyocytes
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Single Nanocrown Electrodes for High‐Quality Intracellular Recording of Cardiomyocytes
Do you wish to request the book?
Single Nanocrown Electrodes for High‐Quality Intracellular Recording of Cardiomyocytes
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Single Nanocrown Electrodes for High‐Quality Intracellular Recording of Cardiomyocytes
2025
Overview
Nanoelectrode arrays (NEAs) are emerging as promising technologies for minimally‐invasive, parallel intracellular recording. These vertical electrodes, typically hundreds of nanometers in diameter and micrometers in height, provide a means for gentle electroporation and reversible membrane permeabilization to achieve intracellular recording. Prior studies have used 5–9 vertical nanostructures per recording channel to enhance device robustness and signal strength. However, this approach complicates the establishment of a one‐to‐one correspondence between cells and electrodes. In this study, devices with recording channels featuring 1‐, 3‐, 5‐, or 9‐ vertical nanocrowns electrode arrays (NcEAs) are developed in the same device. Channels with vertical nanoelectrodes of different geometries, as well as non‐vertical electrodes, such as shallow hole electrodes and large flat electrodes, are also incorporated. These measurements demonstrate that a single NcEA not only provides high‐quality iAP recordings but also excels at preserving the intracellular waveform. In contrast, non‐vertical electrodes detect intracellular‐like signals with distorted waveforms and are not suitable for cardiac intracellular recordings. These findings highlight the critical role of electrode geometry in improving the precision and reliability of intracellular recording technologies. Intracellular recording devices featuring 1‐, 3‐, 5‐, and 9‐nanocrown electrode arrays (NcEAs) per channel, along with alternative electrode geometries, are developed. Comparative analysis shows that single NcEAs provide high‐fidelity intracellular action potentials, while multi‐nanocrown and non‐vertical electrodes yield distorted signals, emphasizing the importance of nanoelectrode geometry for reliable intracellular cardiac recordings.
Publisher
John Wiley & Sons, Inc,Wiley-VCH
Subject
