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Viral DNA Loads in Various Blood Components of Patients With Epstein-Barr Virus–Positive T-Cell/Natural Killer Cell Lymphoproliferative Diseases
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Viral DNA Loads in Various Blood Components of Patients With Epstein-Barr Virus–Positive T-Cell/Natural Killer Cell Lymphoproliferative Diseases
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Journal Article
Viral DNA Loads in Various Blood Components of Patients With Epstein-Barr Virus–Positive T-Cell/Natural Killer Cell Lymphoproliferative Diseases
2019
Overview
To evaluate diagnostic values for Epstein-Barr virus (EBV) DNA loads in different blood components of patients with EBV-positive T-cell/natural killer cell lymphoproliferative diseases, EBV DNA loads were compared among disease categories in each blood component from 59 patients. Plasma viral loads were significantly higher in “active” disease in chronic active EBV infection. EBV DNA was not detected in the plasma from 7 patients in whom EBV DNA was detected in peripheral blood mononuclear cells and whole blood. Diagnostic cutoff values for whole blood EBV DNA loads of patients with chronic active EBV infection compared with those of infectious mononucleosis was 104.2 (15 800) IU/mL.
Publisher
Oxford University Press
Subject
/ DNA
/ DNA, Viral - isolation & purification
/ Epstein-Barr Virus Infections - blood
/ Epstein-Barr Virus Infections - diagnosis
/ Epstein-Barr Virus Infections - virology
/ Herpesvirus 4, Human - genetics
/ Herpesvirus 4, Human - isolation & purification
/ Humans
/ Immunoproliferative diseases
/ Infectious Mononucleosis - blood
/ Infectious Mononucleosis - diagnosis
/ Infectious Mononucleosis - virology
/ Lymphoproliferative Disorders - blood
/ Lymphoproliferative Disorders - diagnosis
/ Lymphoproliferative Disorders - virology
/ Peripheral blood mononuclear cells
/ VIRUSES
