Journal Article

Cutaneous T-cell lymphoma in Asian patients: a multinational, multicenter, prospective registry study in Asia

Jung, Yun Hwan, Koh, Young Il, Lim Soon Thye, Yeung-Chul, Mun, Park, Seong Kyu, Jae-Yong, Kwak, Kang, Ka Won, Yoon Dok Hyun, Tsai-Yun, Chen, Do Young Rok, Kim, Won Seog, Cosphiadi, Irawan, Lee, Mark Hong, Kim Hyo Jung, Lee, Ho sup, Tay Kuang, Wei Kevin, Hye-Jin, Kang, Lee, Won-Sik, Shim Hyeok, Tan Chen, Lung Daryl, Oh, Sung Yong, Poon, Michelle, Kwon, Jung Hye, Jo Jae Cheol, Ko Young Hyeh, Han, Jae Joon, Yong-Pyo, Lee, Guo, Ye, Ng Soo Chin, Song Yuqin, Zhang Huilai, Sohn, Byeong Seok, Zhao, Weili, Zhu, Jun, Jin, Kim Seok, Yoon, Sang Eun

2021

Overview

Cutaneous T-cell lymphomas (CTCLs) are a group of T-cell lymphomas with low incidence. Due to their indolent characteristics, treatment strategies have not yet been established for advanced CTCLs. In this study, relative incidence of CTCLs in Asia was estimated and the therapeutic outcomes presented based on various treatments currently used in clinics for advanced CTCLs. As part of a prospective registry study of peripheral T-cell lymphoma (PTCL) conducted across Asia, including Korea, China, Taiwan, Singapore, Malaysia, and Indonesia, subgroup analysis was performed for patients with CTCLs. Among 486 patients with PTCL, 37 with CTCL (7.6%) were identified between April 2016 and February 2019. Primary cutaneous ALK-negative anaplastic large cell lymphoma (ALCL, 35.1%) was the most common subtype. With a median follow-up period of 32.1 months, median progression-free survival (PFS) was 53.5 months (95% CI 0.0–122.5), and overall survival was not reached. 14 patients (48.2%) underwent subsequent treatment after the first relapse, but the response rate was 20% with a PFS of 2.2 months (95% CI 0.3–4.0). Six patients received autologous stem cell transplantation (auto-SCT). However, auto-SCT did not result in better outcomes. Additional studies are needed on standard care treatment of advanced or refractory and relapsed CTCLs.

• Publisher: Springer Nature B.V
• Subject: Anaplastic large-cell lymphoma / Autografts / Lymphocytes T / Lymphoma / Medical prognosis / Patients / Stem cell transplantation / Stem cells / Subgroups / Survival / T-cell lymphoma / Transplantation