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Selective serotonin reuptake inhibitor sertraline inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells
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Selective serotonin reuptake inhibitor sertraline inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells
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Journal Article
Selective serotonin reuptake inhibitor sertraline inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells
2016
Overview
We examined the effects of the selective serotonin reuptake inhibitor (SSRI) sertraline on voltage-dependent K
+
(Kv) channels in freshly isolated rabbit coronary arterial smooth muscle cells using the voltage-clamp technique. Sertraline decreased the Kv channel current in a dose-dependent manner, with an IC
50
value of 0.18 μM and a slope value (Hill coefficient) of 0.61. Although the application of 1 μM sertraline did not affect the steady-state activation curves, sertraline caused a significant, negative shift in the inactivation curves. Pretreatment with another SSRI, paroxetine, had no significant effect on Kv currents and did not alter the inhibitory effects of sertraline on Kv currents. From these results, we concluded that sertraline dose-dependently inhibited Kv currents independently of serotonin reuptake inhibition by shifting inactivation curves to a more negative potential.
Publisher
Springer India
Subject
/ Biomedical and Life Sciences
/ Coronary Vessels - drug effects
/ Coronary Vessels - pathology
/ Dose-Response Relationship, Drug
/ myocytes
/ Myocytes, Smooth Muscle - drug effects
/ Myocytes, Smooth Muscle - pathology
/ Paroxetine - administration & dosage
/ Potassium Channels, Voltage-Gated - biosynthesis
/ Potassium Channels, Voltage-Gated - metabolism
/ Rabbits
/ Serotonin Uptake Inhibitors - administration & dosage
/ Sertraline - administration & dosage
/ Zoology
