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Cell growth inhibitory effects of polyphenols with naphthalene skeleton against cisplatin-resistant ovarian cancer cells

by Shin, Soon Young , Park, Jihyun , Jo, Geunhyeong , Lee, Ji Hye , Koh, Dongsoo , Lee, Youngshim , Lim, Yoongho , Hwang, Doseok

in animal ovaries / Anticancer properties / Antitumor agents / Applied Microbiology / Biological Techniques / Bioorganic Chemistry / Cell growth / chalcones / Chemistry / Chemistry and Materials Science / Cisplatin / Drug resistance / drug therapy / flavanones / Flavones / Molecular structure / Naphthalene / neoplasm cells / Ovarian cancer / ovarian neoplasms / Pharmacology / Pharmacophores / Polyphenols / Pyrazole / quantitative structure-activity relationships / 농학

2018

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Cell growth inhibitory effects of polyphenols with naphthalene skeleton against cisplatin-resistant ovarian cancer cells

by Shin, Soon Young , Park, Jihyun , Jo, Geunhyeong , Lee, Ji Hye , Koh, Dongsoo , Lee, Youngshim , Lim, Yoongho , Hwang, Doseok

2018

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Cell growth inhibitory effects of polyphenols with naphthalene skeleton against cisplatin-resistant ovarian cancer cells

by Shin, Soon Young , Park, Jihyun , Jo, Geunhyeong , Lee, Ji Hye , Koh, Dongsoo , Lee, Youngshim , Lim, Yoongho , Hwang, Doseok

2018

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Journal Article

Cell growth inhibitory effects of polyphenols with naphthalene skeleton against cisplatin-resistant ovarian cancer cells

Shin, Soon Young,

Park, Jihyun,

Jo, Geunhyeong,

Lee, Ji Hye,

Koh, Dongsoo,

Lee, Youngshim,

Lim, Yoongho,

Hwang, Doseok

2018

Overview

Cisplatin often shows the drug resistance which could limit the chemotherapeutic efficacy. Thus, it is necessary to develop anticancer agents against cisplatin-resistant cancer cells. To identify pharmacophores exhibiting the cell growth inhibitory effect against cisplatin-resistant A2780/Cis ovarian cancer cells, we prepared 35 synthetic polyphenols bearing naphthalene skeleton including naphthalenyl chalcones, naphthalenyl flavones, naphthalenyl flavanones, 4,5-dihydro-1 H -pyrazol-3-yl)naphthalen-2-ols, naphthalen-1-yl- N -phenyl-4,5-dihydro-1 H -pyrazole-1-carbothioamides, and 4,5-dihydro-1 H -pyrazol-3-yl)naphthalen-1-ol. The correlation between their inhibitory effects and structural properties was evaluated using hologram quantitative structure activity relationship and comparative molecular field analysis. The pharmacophores derived here can lead us to design new polyphenols against the growth of cisplatin-resistant cells.

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Publisher

Springer Netherlands,Springer Nature B.V,한국응용생명화학회

Subject

animal ovaries

/ Anticancer properties

/ Antitumor agents

/ Applied Microbiology

/ Biological Techniques

/ Bioorganic Chemistry

/ Cell growth