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Etiology of central nervous system infections in the Philippines and the role of serum C-reactive protein in excluding acute bacterial meningitis
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Etiology of central nervous system infections in the Philippines and the role of serum C-reactive protein in excluding acute bacterial meningitis
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Journal Article
Etiology of central nervous system infections in the Philippines and the role of serum C-reactive protein in excluding acute bacterial meningitis
1999
Overview
Objectives: The value of measurements of serum C-reactive protein (CRP) in differentiating central nervous system (CNS) infections of varying etiologies in the Philippines was investigated.
Methods: A wide array of bacteriologic and virologic methods as well as computed tomography, typical clinical presentation, and autopsy were used for etiologic diagnosis.
Results: Among 103 patients with CNS infection, etiology was identified in 60 (58%) cases. Bacteria were found in 19 (including 7
Streptococcus pneumoniae, 5
Haemophilus influenzae, 3
Neisseria meningitidis), tuberculosis in 4, viruses in 38 (including 20 coxsackievirus, 8 measles, 4 adenovirus, and 4 poliovirus infections), and brain abscess in 3 patients. C-reactive protein was elevated on admission in all 18 cases of bacterial meningitis tested, exceeding 50 mg/L in 17 (94%), and was not affected by prior antibacterial treatment. The mean CRP was significantly higher in the bacterial group than in the viral group (207 ± 111 mg/L vs. 39 ± 34 mg/L; P < 0.001). In the viral group one third had CRP above 50 mg/L. In patients with tuberculous meningitis, brain abscess, or cryptococcal meningitis, CRP was moderately to highly elevated.
Conclusions: In the presence of a normal CRP concentration (below 10 mg/mL) acute bacterial meningitis is excluded even in a developing country setting and antimicrobial therapy is not warranted.
Publisher
Elsevier Ltd,Elsevier,Decker Periodicals, Inc
Subject
/ Antibodies, Bacterial - blood
/ Antibodies, Bacterial - cerebrospinal fluid
/ Bacterial diseases of the nervous system. Bacterial myositis
/ Biological and medical sciences
/ C-Reactive Protein - analysis
/ Central Nervous System Infections - blood
/ Central Nervous System Infections - cerebrospinal fluid
/ Central Nervous System Infections - diagnosis
/ Central Nervous System Infections - microbiology
/ Central Nervous System Infections - virology
/ Child
/ Humans
/ Infant
/ Meningitis, Bacterial - blood
/ Meningitis, Bacterial - cerebrospinal fluid
/ Meningitis, Bacterial - diagnosis
/ Meningitis, Bacterial - microbiology
/ Peptide Fragments - analysis
