Journal Article

Hepatoprotective effect of seaweeds' methanol extract against carbon tetrachloride-induced poisoning in rats

Ooi, Vincent E.C., Wong, Chun-Kwan, Ang, Put O.

2004

Overview

Issue Title: Asian Pacific Phycology in the 21st Century: Prospects and Challenges Three species of marine brown macroalgae (seaweeds), Myagropsis myagroides, Sargassum henslowianum and S. siliquastrum collected from Tung Ping Chau, Hong Kong were studied for their curative effects on hepatotoxicity caused by carbon tetrachloride (CCl^sub 4^) in male Sprague-Dawley rats. A single suitable oral dose of 1.25 ml kg^sup -1^ of 20% CCl^sub 4^ was used as a model hepatotoxin to produce significantly elevated levels of serum glutamic pyruvic transaminase (SGPT) and glutamic oxaloacetic transaminase (SGOT). Gavage oral administration of 300 mg kg^sup -1^ of methanol crude extract from S. siliquastrum 6 h post-treatment of CCl^sub 4^ significantly reduced the CCl^sub 4^-induced acute elevation in the levels of SGPT and SGOT in rats. Similar results, though at a less effective level, were achieved for extracts fromS. henslowianum and M. myagroides. These results indicate that these seaweeds may contain some active principles in their methanol extracts which acted as an antidote against the hepatotoxicity induced by CCl^sub 4^. Further investigation is necessary to clarify and characterize the active component(s) in the extracts.[PUBLICATION ABSTRACT]

• Publisher: Springer,Springer Nature B.V
• Subject: Algae / Biological and medical sciences / Fundamental and applied biological sciences. Psychology / Hepatotoxicity / Methanol / Myagropsis myagroides / Phycology / Plant cytology, morphology, systematics, chorology and evolution / Rodents / Sargassum henslowianum / Sargassum siliquastrum / Thallophyta