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Probiotics Clostridium Butyricum and Bacillus Subtilis Ameliorate Intestinal Tumorigenesis

by Chen, Zhao-Fei , Li, Min , Ren, Lin-Lin , Wang, Ji-Lin , Chen, Ying-Xuan , Chen, Hao-Yan , Ai, Luo-Yan , Yu, Ya-Nan , Ma, Xiong , Xu, Jie , Fang, Jing-Yuan , Qin, Wen-Xin , Shen, Nan , Hong, Jie , Yu, Jun

in 1,2-Dimethylhydrazine / Administration, Oral / Animals / Antitumor activity / Apoptosis / Bacillus subtilis / Bacillus subtilis - physiology / Bacteria / Cancer research / Carcinogenesis / Cell cycle / Cell Cycle Checkpoints / Cell Line, Tumor / Cell proliferation / Clostridium butyricum / Clostridium butyricum - physiology / Colorectal cancer / Colorectal carcinoma / Colorectal Neoplasms - chemically induced / Colorectal Neoplasms - prevention & control / Culture Media, Conditioned / Development and progression / Disease Progression / E coli / Experiments / Flow cytometry / Health aspects / Homeostasis / Inflammation / Inflammation - therapy / Inflammatory bowel disease / Intestine / Lymphocytes / Male / Mice, Inbred C57BL / Microbiota / Preventive medicine / Probiotics / Spleen / Standard deviation / Tumorigenesis

2015

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Probiotics Clostridium Butyricum and Bacillus Subtilis Ameliorate Intestinal Tumorigenesis

2015

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Probiotics Clostridium Butyricum and Bacillus Subtilis Ameliorate Intestinal Tumorigenesis

2015

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Journal Article

Probiotics Clostridium Butyricum and Bacillus Subtilis Ameliorate Intestinal Tumorigenesis

Chen, Zhao-Fei,

Li, Min,

Ren, Lin-Lin,

Wang, Ji-Lin,

Chen, Ying-Xuan,

Chen, Hao-Yan,

Ai, Luo-Yan,

Yu, Ya-Nan,

Ma, Xiong,

Xu, Jie,

Fang, Jing-Yuan,

Qin, Wen-Xin,

Shen, Nan,

Hong, Jie,

Yu, Jun

2015

Overview

To investigate the antitumor effects of probiotics Clostridium butyricum and Bacillus subtilis on colorectal cancer (CRC) progression. The effects of C. butyricum and B. subtilis on CRC cells were studied. Male C57BL/6 mice with 1,2-dimethylhydrazine dihydrochloride (DMH)-induced CRC were intervened by these two probiotics and the antitumor effects were examined by comparing the tumor incidence and detecting the inflammatory and immune-related markers. C. butyricum and B. subtilis inhibited the proliferation of CRC cells, caused cell cycle arrest and promoted apoptosis. In vivo, these two probiotics inhibited the development of DMH-induced CRC. The molecular mechanism involved reduced inflammation and improved immune homeostasis. This work establishes a basis for the protective role of probiotics B. subtilis and C. butyricum in intestinal tumorigenesis.

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Publisher

Future Medicine Ltd

Subject

1,2-Dimethylhydrazine

/ Administration, Oral

/ Animals

/ Antitumor activity

/ Apoptosis

/ Bacillus subtilis

/ Bacillus subtilis - physiology