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Study on antibacterial effect of 45S5 Bioglass
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Journal Article
Study on antibacterial effect of 45S5 Bioglass
2009
Overview
Previous studies have shown that bioactive glasses possessed antibacterial effect on common bacteria due to the high aqueous pH value caused by the bioactive glass dissolution. In the present study, the efficiency of the antibacterial effect of 45S5 Bioglass
®
(45S5 BAG) against
S. aureus
,
S. epidermidis
and
E. coli
and its mechanism were investigated. The results showed that 45S5 BAG exhibited a strong antibacterial effect against the bacteria, and the sensitivity of gram-negative and gram-positive bacteria to Bioglass was different. Furthermore, a dose-dependent bacterial adhesion on 45S5 BAG particles and the formation of needle-like Bioglass debris were observed, which resulted in the damage of cell walls and inactivation of bacteria. The results suggested that both the high pH and bioglass debris on the surface of bacteria may be the possible mechanisms of the antibacterial effect of 45S5 BAG particulates.
Publisher
Springer US,Springer Nature B.V
Subject
Anti-Bacterial Agents - chemistry
/ Anti-Bacterial Agents - pharmacology
/ Bacterial Adhesion - drug effects
/ Biocompatible Materials - chemistry
/ Biomedical Engineering and Bioengineering
/ Ceramics
/ Chemistry and Materials Science
/ E coli
/ Escherichia coli - drug effects
/ Glass
/ Microscopy, Electron, Transmission
/ Regenerative Medicine/Tissue Engineering
/ Staphylococcus aureus - drug effects
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