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Serial magnetic resonance imaging of experimental atherosclerosis detects lesion fine structure, progression and complications in vivo
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Serial magnetic resonance imaging of experimental atherosclerosis detects lesion fine structure, progression and complications in vivo
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Journal Article
Serial magnetic resonance imaging of experimental atherosclerosis detects lesion fine structure, progression and complications in vivo
1995
Overview
A major problem in the study of lesions of atherosclerosis is the difficulty of imaging noninvasively the lesions and following their progression
in vivo
. To address this problem, we have developed advanced magnetic resonance techniques to noninvasively and serially image advanced lesions of atherosclerosis in the rabbit abdominal aorta. Both lumen and wall were imaged with high resolution. Progression of disease, resulting in increase in lesion mass, decrease in arterial lumen, or stenosis, and intralesion complications, can be detected. Images acquired
in vivo
correlate with the fine structure of the lesions of atherosclerosis, including the fibrous cap, necrotic core, and lesion fissures, as verified by gross examination, dissection microscopy, and histology. The ability to noninvasively identify the features of atherosclerotic plaques, has significant implications for determining risks and benefits associated with different therapeutic approaches.
Publisher
Nature Publishing Group US
