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HTLV-1-encoded p30II is a post-transcriptional negative regulator of viral replication
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HTLV-1-encoded p30II is a post-transcriptional negative regulator of viral replication
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Journal Article
HTLV-1-encoded p30II is a post-transcriptional negative regulator of viral replication
2004
Overview
Human T-cell leukemia/lymphoma virus type 1 (HTLV-1) persists despite a vigorous virus-specific host immune response, and causes adult T-cell leukemia and lymphoma in approximately 2% of infected individuals. Here we report that HTLV-1 has evolved a genetic function to restrict its own replication by a novel post-transcriptional mechanism. The HTLV-1-encoded p30
II
is a nuclear-resident protein that binds to, and retains in the nucleus, the doubly spliced mRNA encoding the Tax and Rex proteins. Because Tex and Rex are positive regulators of viral gene expression
1
,
2
, their inhibition by p30
II
reduces virion production. p30
II
inhibits virus expression by reducing Tax and Rex protein expression.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Gene Expression Regulation, Viral
/ Gene Products, rex - genetics
/ Gene Products, rex - metabolism
/ Human T-lymphotropic virus 1 - genetics
/ Human T-lymphotropic virus 1 - physiology
/ Humans
/ letter
/ Leukemia
/ Lymphoma
/ Recombinant Fusion Proteins - genetics
/ Recombinant Fusion Proteins - metabolism
/ Retroviridae Proteins - genetics
