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Early Clinical Response as a Predictor of Late Treatment Success in Patients With Acute Bacterial Skin and Skin Structure Infections: Retrospective Analysis of 2 Randomized Controlled Trials

by Prokocimer, Philippe , De Anda, Carisa , Das, Anita F. , Nathwani, Dilip , Sandison, Taylor , Corey, Ralph

in Anti-Bacterial Agents - therapeutic use / Bacteria / Bacterial infections / Clinical trials / Clinical Trials, Phase III as Topic / Data analysis / Humans / Linezolid - therapeutic use / Medical treatment / Models, Statistical / Organophosphates - therapeutic use / Oxazoles - therapeutic use / Randomized Controlled Trials as Topic / Retrospective Studies / Sensitivity and Specificity / Skin diseases / Skin Diseases, Bacterial - drug therapy / Skin Diseases, Bacterial - microbiology / Time Factors / Treatment Outcome

2017

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Early Clinical Response as a Predictor of Late Treatment Success in Patients With Acute Bacterial Skin and Skin Structure Infections: Retrospective Analysis of 2 Randomized Controlled Trials

by Prokocimer, Philippe , De Anda, Carisa , Das, Anita F. , Nathwani, Dilip , Sandison, Taylor , Corey, Ralph

2017

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Early Clinical Response as a Predictor of Late Treatment Success in Patients With Acute Bacterial Skin and Skin Structure Infections: Retrospective Analysis of 2 Randomized Controlled Trials

by Prokocimer, Philippe , De Anda, Carisa , Das, Anita F. , Nathwani, Dilip , Sandison, Taylor , Corey, Ralph

2017

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Journal Article

Early Clinical Response as a Predictor of Late Treatment Success in Patients With Acute Bacterial Skin and Skin Structure Infections: Retrospective Analysis of 2 Randomized Controlled Trials

Prokocimer, Philippe,

De Anda, Carisa,

Das, Anita F.,

Nathwani, Dilip,

Sandison, Taylor,

Corey, Ralph

2017

Overview

In the treatment of acute bacterial skin and skin structure infections, pooled data from 2 clinical trials (N = 1333 patients) showed that programmatic and investigator-assessed early treatment success both had a high positive predictive value (94.3%-100.0%) for late clinical cure, including among hospitalized patients. The negative predictive value of programmatic early success was <20%. These exploratory findings require prospective real-world evaluation. NCT01170221; NCT01421511.

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Publisher

Oxford University Press

Subject

Anti-Bacterial Agents - therapeutic use

/ Bacteria

/ Bacterial infections

/ Clinical trials

/ Clinical Trials, Phase III as Topic

/ Data analysis

/ Humans