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Immunomodulatory Effect of Lactobacillus casei in a Murine Model of Colon Carcinogenesis
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Immunomodulatory Effect of Lactobacillus casei in a Murine Model of Colon Carcinogenesis
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Journal Article
Immunomodulatory Effect of Lactobacillus casei in a Murine Model of Colon Carcinogenesis
2020
Overview
We previously reported beneficial effects of the probiotic strain
Lactobacillus casei
393 in hindering colon carcinogenesis in a
1
,
2
-
dimethylhydrazine (DMH)
-induced BALB/c mouse model of colon cancer. In the present study, we investigated the effect of preventive administration of
L. casei
393 on the levels of selected pro- and anti-inflammatory circulating cytokines, as well as subpopulations of splenic T cells. The resulting experimental data on IFNγ, TNFα, IL-10, and colon histological features demonstrated that administration of
L. casei
2 weeks before DMH treatment impaired the pro-inflammatory effect of DMH, while maintaining the levels of the three cytokines as well as colon histology; it also modulated splenic CD4
+
, CD8
+
, and NK T cell subpopulations. The preventive administration of
L. casei
to DMH-treated mice increased IL-17A synthesis and Treg percentages, further indicating a tumor-protecting role. Together, the results suggest that the colon-cancer-protective properties of
L. casei
393 involve the dampening of inflammation through cytokine homeostasis and the maintenance of a healthy T cell subpopulation dynamic. For these reasons, probiotics such as
L. casei
may contribute to the health of the host as they promote optimal control of the immune response. Further, they may be used as prophylactic agents in combination with standard therapies against colon cancer.
Publisher
Springer US,Springer Nature B.V
Subject
