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Viremic Relapse after HIV-1 Remission in a Perinatally Infected Child
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Viremic Relapse after HIV-1 Remission in a Perinatally Infected Child
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Journal Article
Viremic Relapse after HIV-1 Remission in a Perinatally Infected Child
2015
Overview
Recently the “Mississippi Child” was reported as having a prolonged clearance of HIV viremia after the initiation of antiretroviral therapy shortly after birth. Further follow-up of this case is now reported.
To the Editor:
We previously reported
1
the remission of human immunodeficiency virus type 1 (HIV-1) in a perinatally infected child — the “Mississippi Child.” After receiving antiretroviral therapy (ART) between 30 hours and 18 months of age, this child had persistently undetectable plasma HIV-1 viremia for 12 months in the absence of HIV-1–specific immune responses. At the time of the initial case report, it was uncertain whether HIV-1 reservoirs were established that could lead to rebound viremia.
After the first report, the child had persistently undetectable plasma HIV-1 RNA levels, as assessed by means of standard clinical assays, with normal . . .
Publisher
Massachusetts Medical Society
