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Parkinson’s disease laterality: a 11C-PE2I PET imaging study

by Martin-Bastida, Antonio , Piccini, Paola , Palfi Stéphane , Rosser, Anne , Winkler, Christian , Daft Danielle , Mahlknecht Philipp , Widner Hakan , Morris, Robert , Hewitt, Sam , Bjartmarz Hjalmar , Lao-Kaim, Nicholas P , He, Xiaoling , Barker, Roger A , Piroth, Tobias , Church, Alistair , Peall Kathryn , Tyers, Pamela , Zeng, Zhou , Parmar Malin , Kefalopoulou Zenobia , Paul, Gesine , Biswas, Dayal , Nelander-Wahlestedt Jenny , Wijeyekoon Ruwani , Foltynie, Thomas , Gurruchaga Jean Marc , Guzman, Natalie Valle , Lindvall Olle , Andreas-Antonios, Roussakis , Lazic, Stanley E , Moore, Sarah , Farrell, Krista , Björklund, Anders , Dunnett, Stephen

in Asymmetry / Computed tomography / Dopamine receptors / Dopamine transporter / Hemispheric laterality / Movement disorders / Neostriatum / Neurodegeneration / Neurodegenerative diseases / Neurology / Parkinson's disease

2021

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2021

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2021

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Journal Article

Parkinson’s disease laterality: a 11C-PE2I PET imaging study

Martin-Bastida, Antonio,

Piccini, Paola,

Palfi Stéphane,

Rosser, Anne,

Winkler, Christian,

Daft Danielle,

Mahlknecht Philipp,

Widner Hakan,

Morris, Robert,

Hewitt, Sam,

Bjartmarz Hjalmar,

Lao-Kaim, Nicholas P,

He, Xiaoling,

Barker, Roger A,

Piroth, Tobias,

Church, Alistair,

Peall Kathryn,

Tyers, Pamela,

Zeng, Zhou,

Parmar Malin,

Kefalopoulou Zenobia,

Paul, Gesine,

Biswas, Dayal,

Nelander-Wahlestedt Jenny,

Wijeyekoon Ruwani,

Foltynie, Thomas,

Gurruchaga Jean Marc,

Guzman, Natalie Valle,

Lindvall Olle,

Andreas-Antonios, Roussakis,

Lazic, Stanley E,

Moore, Sarah,

Farrell, Krista,

Björklund, Anders,

Dunnett, Stephen

2021

Overview

Asymmetry of striatal dopaminergic deficits and motor symptoms is a typical characteristic of idiopathic Parkinson’s disease (PD). This study aims to characterise the trend of asymmetry in moderate-stage PD. We performed a 19-month longitudinal study in 27 patients with PET-CT imaging and appropriate clinical assessments. 11C-PE2I non-displaceable binding potential (BPND) was calculated bilaterally for the striatum at baseline and follow-up to estimate the in vivo density of striatal dopamine transporters (DAT). Changes in striatal 11C-PE2I BPND over time were more prominent in the ipsilateral as compared to contralateral side. Changes in MDS-UPDRS-III (motor component of the Movement Disorders Society Unified PD Rating Scale) were not different between the clinically most and least affected body sides. Our data support that the asymmetry in striatal dopaminergic degeneration becomes less prominent in moderate-stage PD. In contrast, during the above period, the asymmetry of motor symptoms was maintained between the clinically most and least affected body sides.

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Publisher

Springer Nature B.V

Subject

Asymmetry

/ Computed tomography

/ Dopamine receptors

/ Dopamine transporter

/ Hemispheric laterality

/ Movement disorders

/ Neostriatum