Asset Details
Do you wish to reserve the book?
Activation of ventral tegmental area dopamine neurons produces wakefulness through dopamine D2-like receptors in mice
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Activation of ventral tegmental area dopamine neurons produces wakefulness through dopamine D2-like receptors in mice
Do you wish to request the book?
Activation of ventral tegmental area dopamine neurons produces wakefulness through dopamine D2-like receptors in mice
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Activation of ventral tegmental area dopamine neurons produces wakefulness through dopamine D2-like receptors in mice
2017
Overview
A growing body of evidence suggests that dopamine plays a role in sleep–wake regulation, but the dopamine-producing brain areas that control sleep–wake states are unclear. In this study, we chemogenetically activated dopamine neurons in the ventral midbrain of mice to examine the role of these neurons in sleep–wake regulation. We found that activation of dopamine neurons in the ventral tegmental area (VTA), but not in the substantia nigra, strongly induced wakefulness, although both cell populations expressed the neuronal activity marker c-Fos after chemogenetic stimulation. Analysis of the pattern of behavioral states revealed that VTA activation increased the duration of wakefulness and decreased the number of wakefulness episodes, indicating that wakefulness was consolidated by VTA activation. The increased wakefulness evoked by VTA activation was completely abolished by pretreatment with the dopamine D
2
/D
3
receptor antagonist raclopride, but not by the D
1
receptor antagonist SCH23390. These findings indicate that the activation of VTA dopamine neurons promotes wakefulness via D
2
/D
3
receptors.
Publisher
Springer Berlin Heidelberg
Subject
