Asset Details
Do you wish to reserve the book?
Brain-derived neurotrophic factor in neurodegenerative diseases
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Brain-derived neurotrophic factor in neurodegenerative diseases
Do you wish to request the book?
Brain-derived neurotrophic factor in neurodegenerative diseases
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Brain-derived neurotrophic factor in neurodegenerative diseases
2009
Overview
Changes in the levels and activities of neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), have been described in a number of neurodegenerative disorders, including Huntington disease, Alzheimer disease and Parkinson disease. It is only in Huntington disease, however, that gain-of-function and loss-of-function experiments have linked BDNF mechanistically with the underlying genetic defect. Altogether, these studies have led to the development of experimental strategies aimed at increasing BDNF levels in the brains of animals that have been genetically altered to mimic the aforementioned human diseases, with a view to ultimately influencing the clinical treatment of these conditions. In this article, we will review the current knowledge about the involvement of BDNF in a number of neurodegenerative diseases, with particular emphasis on Huntington disease, and will provide the rationale for and discuss the problems in proposing BDNF treatment as a beneficial and feasible therapeutic approach in the clinic.
Publisher
Nature Publishing Group
Subject
/ Brain-derived neurotrophic factor
/ Brain-Derived Neurotrophic Factor - genetics
/ Brain-Derived Neurotrophic Factor - metabolism
/ Brain-Derived Neurotrophic Factor - therapeutic use
/ Humans
/ Neurodegenerative Diseases - classification
/ Neurodegenerative Diseases - genetics
/ Neurodegenerative Diseases - metabolism
/ Neurodegenerative Diseases - therapy
