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ECDC/EFSA/EMA second joint report on the integrated analysis of the consumption of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from humans and food‐producing animals
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ECDC/EFSA/EMA second joint report on the integrated analysis of the consumption of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from humans and food‐producing animals
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Journal Article
ECDC/EFSA/EMA second joint report on the integrated analysis of the consumption of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from humans and food‐producing animals
2017
Overview
The second ECDC/EFSA/EMA joint report on the integrated analysis of antimicrobial consumption (AMC) and antimicrobial resistance (AMR) in bacteria from humans and food-producing animals addressed data obtained by the Agencies' EU-wide surveillance networks for 2013-2015. AMC in both sectors, expressed in mg/kg of estimated biomass, were compared at country and European level. Substantial variations between countries were observed in both sectors. Estimated data on AMC for pigs and poultry were used for the first time. Univariate and multivariate analyses were applied to study associations between AMC and AMR. In 2014, the average AMC was higher in animals (152 mg/kg) than in humans (124 mg/kg), but the opposite applied to the median AMC (67 and 118 mg/kg, respectively). In 18 of 28 countries, AMC was lower in animals than in humans. Univariate analysis showed statistically-significant (p < 0.05) associations between AMC and AMR for fluoroquinolones and
in both sectors, for 3rd- and 4th-generation cephalosporins and
in humans, and tetracyclines and polymyxins and
in animals. In humans, there was a statistically-significant association between AMC and AMR for carbapenems and polymyxins in
. Consumption of macrolides in animals was significantly associated with macrolide resistance in
in animals and humans. Multivariate analyses provided a unique approach to assess the contributions of AMC in humans and animals and AMR in bacteria from animals to AMR in bacteria from humans. Multivariate analyses demonstrated that 3rd- and 4th-generation cephalosporin and fluoroquinolone resistance in
from humans was associated with corresponding AMC in humans, whereas resistance to fluoroquinolones in
spp. and
spp. from humans was related to consumption of fluoroquinolones in animals. These results suggest that from a 'One-health' perspective, there is potential in both sectors to further develop prudent use of antimicrobials and thereby reduce AMR.
Publisher
John Wiley and Sons Inc
Subject
