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Moxibustion modulates gut microbiota and improves bone marrow hematopoiesis in mice with myelosuppression-induced aplastic anemia
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Moxibustion modulates gut microbiota and improves bone marrow hematopoiesis in mice with myelosuppression-induced aplastic anemia
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Moxibustion modulates gut microbiota and improves bone marrow hematopoiesis in mice with myelosuppression-induced aplastic anemia
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Journal Article
Moxibustion modulates gut microbiota and improves bone marrow hematopoiesis in mice with myelosuppression-induced aplastic anemia
2025
Overview
To observe the effects of moxibustion on the hematopoietic function in mice with aplastic anemia (AA) induced by bone marrow (BM) suppression, and to investigate the intervention effects of moxibustion on AA from the perspective of intestinal bacteria.
A total of 24 C57BL/6 J male mice were randomly and evenly divided into control, model and moxibustion groups. The myelosuppression-induced AA model was established by cyclophosphamide (CTX) and cyclosporine (Cs) intraperitoneal injection. Mice in the moxibustion group were intervened in mild moxibustion at unilateral “Zusanli(ST36)” acupoint for 15 min per day, and the sides were switched the next day. The intervention of mild moxibustion lasted 60 days consecutively. The red blood cell (RBC), white blood cell (WBC), platelet (PLT) counts and haemoglobin (Hb) concentration levels of mice in each group were detected by peripheral blood cells count staining, and the BM hematopoietic cells and hematopoietic structures were observed by BM smear Wright-Giemsa staining and HE staining. 16SrDNA sequencing was used to analyze the gut bacterial species abundance and diversity in mice from each group.
After all the intervention, compared to the control group, the model group had lower levels of RBC, WBC, PLT counts and Hb concentration in peripheral blood (P < 0.05) and fewer hematopoietic cells and hematopoietic structures; compared to the model group, moxibustion group had higher levels of RBC, WBC, PLT counts and Hb concentration in peripheral blood (P < 0.05), and more BM hematopoietic cells and hematopoietic structures. Gut flora showed that moxibustion increased the species richness and diversity of intestinal bacteria in mice; compared with the control group, the relative abundance of Faecalibaculum and Anaeroplasmataceae in the model group was higher (P < 0.05); whereas, the relative abundance of Faecalibaculum and Anaeroplasmataceae in the moxibustion group was lower (P < 0.05) when compared with the model group. In addition, Faecalibaculum was significantly correlated with RBC, WBC, PLT count and Hb concentration (P < 0.05).
Moxibustion can improved BM histology, restored hematopoietic cells function, and increased peripheral blood cells count and Hb concentration in AA mice. The mechanism may be related to the fact that moxibustion regulates the abundance of specific intestinal bacteria to maintain the stability of the flora structure.
Publisher
Elsevier B.V,KeAi Publishing Communications Ltd,KeAi Communications Co., Ltd
Subject
