Journal Article

Child maltreatment and telomere length in middle and older age: retrospective cohort study of 141 748 UK Biobank participants

Pell, Jill P., Ho, Frederick K., Chan, Ko Ling, Ip, Patrick, Zhou, Ziyi, Minnis, Helen, Lo, Camilla K. M., Chung, Rachel S. Y., Shiels, Paul G.

2023

Overview

There is evidence that child maltreatment is associated with shorter telomere length in early life. This study aims to examine if child maltreatment is associated with telomere length in middle- and older-age adults. This was a retrospective cohort study of 141 748 UK Biobank participants aged 37-73 years at recruitment. Leukocyte telomere length was measured with quantitative polymerase chain reaction, and log-transformed and scaled to have unit standard deviation. Child maltreatment was recalled by participants. Linear regression was used to analyse the association. After adjusting for sociodemographic characteristics, participants with three or more types of maltreatment presented with the shortest telomere lengths ( = -0.05, 95% CI -0.07 to -0.03; < 0.0001), followed by those with two types of maltreatment ( = -0.02, 95% CI -0.04 to 0.00; = 0.02), referent to those who had none. When adjusted for depression and post-traumatic stress disorder, the telomere lengths of participants with three or more types of maltreatment were still shorter ( = -0.04, 95% CI -0.07 to -0.02; = 0.0008). The telomere lengths of those with one type of maltreatment were not significantly different from those who had none. When mutually adjusted, physical abuse ( = -0.05, 95% CI -0.07 to -0.03; < 0.0001) and sexual abuse ( = -0.02, 95% CI -0.04 to 0.00; = 0.02) were independently associated with shorter telomere length. Our findings showed that child maltreatment is associated with shorter telomere length in middle- and older-aged adults, independent of sociodemographic and mental health factors.

• Publisher: Cambridge University Press
• Subject: Abused children / Academic Psychiatry / Adults / Adverse childhood experiences / Age / Age groups / Aging / Biobanks / Cardiovascular disease / Chemical analysis / Child abuse & neglect / Children / Children & youth / Cohort analysis / Emotional abuse / Ethics / Gender / Leukocyte migration / Leukocytes / Likert scale / Mental depression / Mental health / Older people / Oxidative stress / Post traumatic stress disorder / Psychiatry / Questionnaires / Recruitment / Sex crimes / Sexual abuse / Sociodemographics / Stress response / Telomeres / Trauma / Yeast