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The recombination regulator RecX negatively regulates heat-stable antifungal factor (HSAF) biosynthesis in Lysobacter enzymogenes
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The recombination regulator RecX negatively regulates heat-stable antifungal factor (HSAF) biosynthesis in Lysobacter enzymogenes
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Journal Article
The recombination regulator RecX negatively regulates heat-stable antifungal factor (HSAF) biosynthesis in Lysobacter enzymogenes
2023
Overview
Bacteria often use multiple transcription factors to regulate specific biological processes. Biosynthesis of heat-stable antifungal factor (HSAF) is regulated by multiple factors in
Lysobacter enzymogenes
. However, the mechanism of HSAF biosynthesis regulation remains largely unknown. In this study, we screened a potential HSAF biosynthesis regulator, RecX, by a DNA pull-down assay. Deletion of
recX
resulted in a significant increase in the production of HSAF, and overexpression of
recX
significantly suppressed HSAF production. Importantly, our results showe that RecX directly binds to the promoter region of the
lafB
gene to inhibit its transcription and thus decreases HSAF production in
L. enzymogenes
. These findings reveal the novel mechanism of RecX regulation of antifungal antibiotic production in
L. enzymogenes
.
Publisher
BioMed Central,Springer Nature B.V,BMC
Subject
