Asset Details
Do you wish to reserve the book?
Microbial orchestration of neuroimmune crosstalk: from homeostasis to disease
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Microbial orchestration of neuroimmune crosstalk: from homeostasis to disease
Do you wish to request the book?
Microbial orchestration of neuroimmune crosstalk: from homeostasis to disease
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Microbial orchestration of neuroimmune crosstalk: from homeostasis to disease
2025
Overview
The gut-brain-immune axis represents a paradigm shift in understanding systemic homeostasis and disease. While microbial dysbiosis is firmly linked to a spectrum of neurological and immunological disorders, a critical gap persists in our mechanistic understanding of how gut microbes precisely orchestrate the crosstalk between these two systems. This review moves beyond correlation to dissect the causative mechanisms by which microbial metabolites—including short-chain fatty acids, tryptophan derivatives, and neurotransmitters—directly modulate neuroimmune circuits. We synthesize emerging evidence delineating specific molecular circuits that govern microglial maturation, T cell differentiation, and blood–brain barrier integrity, and propose a novel framework for microbiota-mediated neuroimmune regulation. We evaluate cutting-edge microbiota-directed interventions, not merely as generic probiotics, but as precision tools to reestablish neuroimmune homeostasis, thereby outlining a roadmap for next-generation therapeutics in autoimmune, neurodegenerative, and psychiatric diseases.
Publisher
Frontiers Media SA,Frontiers Media S.A
Subject
