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The Association of Atopy with a Gain-of-Function Mutation in the α Subunit of the Interleukin-4 Receptor
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The Association of Atopy with a Gain-of-Function Mutation in the α Subunit of the Interleukin-4 Receptor
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Journal Article
The Association of Atopy with a Gain-of-Function Mutation in the α Subunit of the Interleukin-4 Receptor
1997
Overview
Atopy is characterized by the formation of IgE antibody in persons with a genetic predisposition, who respond with immediate hypersensitivity on exposure to specific allergens. Atopy is common, affecting up to 40 percent of populations of Western societies,
1
–
3
and it underlies the development of allergic diseases in susceptible persons. Although environmental factors such as exposure to antigens have an important role in the development of allergic diseases,
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–
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there is a strong genetic predisposition.
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,
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Recently, a number of atopy susceptibility genes have been identified. Some of these, such as those for interleukin-4
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–
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and several HLA class II . . .
Publisher
Massachusetts Medical Society
Subject
/ Alleles
/ Dermatitis, Atopic - genetics
/ Dermatitis, Atopic - immunology
/ Humans
/ Hypersensitivity, Immediate - genetics
/ Hypersensitivity, Immediate - immunology
/ Polymorphism, Single-Stranded Conformational
/ Proteins
/ Receptors, Interleukin-4 - genetics
