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Secondary Prevention of Venous Thromboembolic Events in Patients With Active Cancer: Enoxaparin Alone Versus Initial Enoxaparin Followed by Warfarin for a 180-Day Period
by
Deitcher, Steven R.
, Fareed, Jawed
, Kessler, Craig M.
, Lyons, Roger M.
, Rigas, James R.
, Merli, Geno
in
Adult
/ Aged
/ Anticoagulants
/ Anticoagulants - therapeutic use
/ Dose-Response Relationship, Drug
/ Drug Therapy, Combination
/ Enoxaparin - therapeutic use
/ Health risk assessment
/ Hormone replacement therapy
/ Humans
/ Middle Aged
/ Neoplasms - complications
/ Neoplasms - mortality
/ Safety
/ Survival Analysis
/ Thromboembolism
/ Thromboembolism - prevention & control
/ Warfarin - therapeutic use
2006
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Secondary Prevention of Venous Thromboembolic Events in Patients With Active Cancer: Enoxaparin Alone Versus Initial Enoxaparin Followed by Warfarin for a 180-Day Period
by
Deitcher, Steven R.
, Fareed, Jawed
, Kessler, Craig M.
, Lyons, Roger M.
, Rigas, James R.
, Merli, Geno
in
Adult
/ Aged
/ Anticoagulants
/ Anticoagulants - therapeutic use
/ Dose-Response Relationship, Drug
/ Drug Therapy, Combination
/ Enoxaparin - therapeutic use
/ Health risk assessment
/ Hormone replacement therapy
/ Humans
/ Middle Aged
/ Neoplasms - complications
/ Neoplasms - mortality
/ Safety
/ Survival Analysis
/ Thromboembolism
/ Thromboembolism - prevention & control
/ Warfarin - therapeutic use
2006
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Secondary Prevention of Venous Thromboembolic Events in Patients With Active Cancer: Enoxaparin Alone Versus Initial Enoxaparin Followed by Warfarin for a 180-Day Period
by
Deitcher, Steven R.
, Fareed, Jawed
, Kessler, Craig M.
, Lyons, Roger M.
, Rigas, James R.
, Merli, Geno
in
Adult
/ Aged
/ Anticoagulants
/ Anticoagulants - therapeutic use
/ Dose-Response Relationship, Drug
/ Drug Therapy, Combination
/ Enoxaparin - therapeutic use
/ Health risk assessment
/ Hormone replacement therapy
/ Humans
/ Middle Aged
/ Neoplasms - complications
/ Neoplasms - mortality
/ Safety
/ Survival Analysis
/ Thromboembolism
/ Thromboembolism - prevention & control
/ Warfarin - therapeutic use
2006
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Secondary Prevention of Venous Thromboembolic Events in Patients With Active Cancer: Enoxaparin Alone Versus Initial Enoxaparin Followed by Warfarin for a 180-Day Period
Journal Article
Secondary Prevention of Venous Thromboembolic Events in Patients With Active Cancer: Enoxaparin Alone Versus Initial Enoxaparin Followed by Warfarin for a 180-Day Period
2006
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Overview
This study evaluated enoxaparin alone versus initial enoxaparin followed by warfarin in secondary prevention of venous thromboembolic events in adults with active malignancy. Cancer patients (n = 122) with acute symptomatic venous thromboembolic events were randomly allocated to receive subcutaneous enoxaparin 1.0 mg/kg every 12 hours for 5 days, followed by 1.0 mg/kg daily (group 1a) or 1.5 mg/kg daily (group 1b) for 175 days, or subcutaneous enoxaparin 1.0 mg/kg every 12 hours for at least 5 days and until a stable international normalized ratio of 2 to 3 was achieved on oral warfarin begun on day 2 and continued to day 180 (group 2). There were no significant differences in major and minor bleeding rates between treatment groups. No bleeding events were intracranial or fatal. Enoxaparin treatment was feasible, generally well tolerated, and effective for a 180-day period in the secondary prevention of venous thromboembolic events in patients with active malignancy.
Publisher
SAGE Publications,SAGE PUBLICATIONS, INC
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