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Developments in Antibiotic-Eluting Scaffolds for the Treatment of Osteomyelitis
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Developments in Antibiotic-Eluting Scaffolds for the Treatment of Osteomyelitis
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Journal Article
Developments in Antibiotic-Eluting Scaffolds for the Treatment of Osteomyelitis
2020
Overview
Osteomyelitis is a devastating disease caused by the infection of bone tissue and is associated with significant morbidity and mortality. It is treated with antibiotic therapy and surgical debridement. A high dose of systemic antibiotics is often required due to poor bone penetration and this is often associated with unacceptable side-effects. To overcome this, local, implantable antibiotic carriers such as polymethyl methacrylate have been developed. However, this is a non-biodegradable material that requires a second surgery to be removed. Attention has therefore shifted to new antibiotic-eluting scaffolds which can be created with a range of unique properties. The purpose of this review is to assess the level of evidence that exists for these novel local treatments. Although this field is still developing, these strategies seem promising and provide hope for the future treatment of chronic osteomyelitis.
Publisher
MDPI AG
Subject
