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Hydroxyurea Dose Escalation for Sickle Cell Anemia in Sub-Saharan Africa
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Hydroxyurea Dose Escalation for Sickle Cell Anemia in Sub-Saharan Africa
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Journal Article
Hydroxyurea Dose Escalation for Sickle Cell Anemia in Sub-Saharan Africa
2020
Overview
Hydroxyurea increases expression of fetal hemoglobin and decreases clinical complications in children with sickle cell anemia. A trial of a higher dose (30 mg per kg per day) as compared with a standard dose (20 mg per kg) in children in sub-Saharan Africa showed improved outcomes without increased toxicity.
