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Differential impact of classical and non-canonical NF-κB pathway-related gene expression on the survival of breast cancer patients
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Differential impact of classical and non-canonical NF-κB pathway-related gene expression on the survival of breast cancer patients
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Journal Article
Differential impact of classical and non-canonical NF-κB pathway-related gene expression on the survival of breast cancer patients
2019
Overview
Inflammation is a well-known driver of carcinogenesis and cancer progression, often attributed to the tumor microenvironment. However, tumor cells themselves are capable of secreting a variety of inflammatory molecules, leading to the activation of specific signaling pathways that promote tumor progression. The NF-κB signaling pathway is one of the most important connections between inflammation and tumorigenesis. NF-κB is a superfamily of transcription factors that plays an important role in several types of hematological and solid tumors, including breast cancer. However, the role of the NF-κB pathway in the survival of breast cancer patients is poorly studied. In this study, we analyzed and related the expression of both canonical and alternative NF-κB pathways and selected target genes with the relapse-free and overall survival of breast cancer patients. We used the public database Kaplan-Meier plotter (KMplot) which includes gene expression data and survival information of 3951 breast cancer patients. We found that the expression of
was associated with poor relapse-free survival in patients with ER-positive tumors. Moreover, the expression of
and
was associated with poor relapse-free and overall survival. In contrast, expression of
,
and
from the canonical pathway, and
and
from the alternative pathway correlated with better relapse-free survival also when the patients were classified by their hormonal and nodal status. Our study suggests that the expression of genes of the canonical and alternative NF-κB pathways is ultimately critical for tumor persistence. Understanding the communication between both pathways would help to find better therapeutic and prophylactic targets to prevent breast cancer progression and relapse.
Publisher
Ivyspring International Publisher Pty Ltd,Ivyspring International Publisher
