Journal Article

Nephrotoxicity of iodixanol versus iopamidol in patients undergoing peripheral angiography with or without endovascular therapy

Xu, Bo, Yu-bao, Zou, Yue-jin, Yang, Xiong-jing, Jiang, Dong, Hui, Chen, Yang, Meng, Peng, Wu-qiang, Che, Run-lin Gao, Hong-liang, Xiong

2018

Overview

PurposeTo compare the nephrotoxic effects of iodixanol and iopamidol in patients undergoing peripheral angiography.MethodsPatients scheduled for peripheral angiography were randomly assigned to the iodixanol group (n = 463) and iopamidol group (n = 458). The primary endpoint was the incidence of contrast associated acute kidney injury (CA-AKI), which was defined as an increase ≥ 25% or ≥ 44.2 µmol/l (0.5 mg/dl) in serum creatinine (SCr) from baseline within 72 h after receiving contrast media (CM). The secondary endpoints were the mean peak SCr increase within 72 h after receiving CM and major adverse renal events (SCr increased by two times after 30 days, the need for dialysis treatment, rehospitalization for acute renal failure, or kidney-related death) during hospitalization and within 30 day postdischarge.ResultsThe incidence of CA-AKI did not differ significantly between the iodixanol group and iopamidol group (18.1% vs. 16.8%; p = 0.595). There was no significant difference in the mean peak SCr increase between the iodixanol group and iopamidol group (10.4 ± 13.0 vs. 10.6 ± 14.3 µmol/l, p = 0.919). There were four patients [1 (0.2%) patient in the iodixanol group and 1 (0.7%) patients in the iopamidol group, p = 0.609] with doubling of SCr; no other adverse renal events were observed.ConclusionsOur data showed that the nephrotoxicity of iodixanol was comparable with that of iopamidol in patients undergoing peripheral angiography.

• Publisher: Springer Nature B.V
• Subject: Angiography / Cardiovascular system / Contrast media / Creatinine / Dialysis / Kidneys / Medical imaging / Patients / Renal failure