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Selective Defect in Plasmacyoid Dendritic Cell Function in a Patient with AIDS-Associated Atypical Genital Herpes Simplex Vegetans Treated with Imiquimod
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Selective Defect in Plasmacyoid Dendritic Cell Function in a Patient with AIDS-Associated Atypical Genital Herpes Simplex Vegetans Treated with Imiquimod
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Journal Article
Selective Defect in Plasmacyoid Dendritic Cell Function in a Patient with AIDS-Associated Atypical Genital Herpes Simplex Vegetans Treated with Imiquimod
2007
Overview
We report a case of acquired immunodeficiency syndrome (AIDS)-associated, acyclovir-refractory genital herpes infection treated with topical imidazoquinoline therapy. The patient's plasmacytoid dendritic cells made a robust interferon-α response following in vitro stimulation with imidazoquinoline but not with herpes simplex virus. We hypothesize that disease resulting from defective herpes simplex virus-stimulated interferon-α may be overcome by stimulating intact alternative pathways.
Publisher
The University of Chicago Press
Subject
/ Adult
/ AIDS-Related Opportunistic Infections - drug therapy
/ AIDS-Related Opportunistic Infections - virology
/ Aminoquinolines - therapeutic use
/ Antiviral Agents - pharmacology
/ Herpes Genitalis - drug therapy
/ Herpesvirus 2, Human - drug effects
/ HIV Infections - complications
/ Humans
/ Interferon Inducers - therapeutic use
/ Male
