Journal Article

Effects of an intraoperative intravenous Bolus Dose of Dexmedetomidine on postoperative catheter-related bladder discomfort in male patients undergoing transurethral resection of bladder tumors: a randomized, double-blind, controlled trial

An, Rui, Cao, Longhui, Lin, Chunnan, Li, Huiting, Lin, Wenqian, Zhang, Tianhua, Tan, Hongying

2024

Overview

Purpose To investigate whether the effect of intravenous bolus doses of dexmedetomidine on postoperative catheter-related bladder discomfort (CRBD) was dose-dependent in male patients undergoing transurethral resection of bladder tumors (TURBT). Methods The study protocol was registered at the Chinese Clinical Trial Registry (ChiCTR 2,000,034,657, date of registration: July 14, 2020). Adult male patients were randomized to one of four groups: placebo (Group C); dexmedetomidine 0.2 µg/kg (Group D 0.2); dexmedetomidine 0.5 µg/kg (Group D 0.5); or dexmedetomidine 1 µg/kg (Group D 1). The primary outcome was the incidence of moderate-to-severe CRBD at 0, 1, 6, 24, and 48 h postoperatively. Results The incidence of moderate-to-severe CRBD was significantly lower in Group D 0.5 and Group D 1 than in Group C at 0 h (13% vs. 40%, P  = 0.006; 8% vs. 40%, P  = 0.001), 1 h (15% vs. 53%, P  < 0.001; 13% vs. 53%, P  < 0.001), and 6 h (10% vs. 32%, P  = 0.025; 8% vs. 32%, P  = 0.009) postoperatively. Compared with baseline, both the MAP and HR were significantly lower in Group D 1 at 1 min ([94 ± 15] vs. [104 ± 13] mm Hg, P  = 0.003; [64 ± 13] vs. [73 ± 13] bpm, P  = 0.001) and 30 min ([93 ± 10] vs. [104 ± 13] mm Hg, P  < 0.001; [58 ± 9] vs. [73 ± 13] bpm, P  < 0.001) postextubation. Conclusion The effect of intravenous bolus doses of dexmedetomidine on postoperative CRBD was dose-independent, whereas intravenous administration of 0.5 µg/kg dexmedetomidine reduced the early postoperative incidence of CRBD with minimal side effects. Trial registration Clinical trial number and registry URL: ChiCTR 2,000,034,657, http://www.chictr.org.cn , date of registration: July 14, 2020.

• Publisher: Springer Berlin Heidelberg,Springer Nature B.V
• Subject: Adult / Biomedical and Life Sciences / Biomedicine / Bladder / Bladder cancer / Catheters / Clinical trials / Dexmedetomidine / Double-Blind Method / Humans / Intravenous administration / Male / Pain, Postoperative - drug therapy / Pain, Postoperative - prevention & control / Pharmacology/Toxicology / Registration / Transurethral Resection of Bladder / Tumors / Urinary Bladder / Urinary Bladder Neoplasms - complications / Urinary Bladder Neoplasms - surgery / Urinary Catheters - adverse effects