Journal Article

Editorial: The Natural Killer Cell Interactome in the Tumor Microenvironment: Basic Concepts and Clinical Application

Villalba, Martín, Anel, Alberto, Pardo, Julián

2020

Overview

[...]at least nine clinical trials using this approach in ovarian cancer patients are currently ongoing.Terrén et al.put the point on the molecular mechanisms that explain the inactivation of NK cell function by the TME through the modulation of NK cell metabolism. [...]in relation with the first original article mentioned at the beginning of this editorial,Lanuza et al.reviewed the available experimental evidences regarding the role of immune checkpoints in NK cell function during physiological and pathological (cancer) conditions, arriving at the conclusion that the main checkpoint molecules targeted in T cells (CTLA-4, PD-1, LAG-3) have low impact in NK cell function during physiological conditions. Conflict of Interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

• Publisher: Frontiers Media SA,Frontiers,Frontiers Media S.A
• Subject: Adaptive immunology / adoptive cell immunotherapy / Cancer / CD223 antigen / Cells / checkpoint inhibitors / Clinical trials / Conflicts of interest / CTLA-4 protein / Hematology / Humans / Immune checkpoint / Immunology / Immunotherapy / Immunotherapy, Adoptive / Innate immunity / Killer Cells, Natural - immunology / Life Sciences / Lymphocytes / Lymphocytes T / Metabolism / Molecular modelling / Natural killer cells / Neoplasms - immunology / Neoplasms - therapy / NK cell / off-the-shelf NK cells / Ovarian cancer / PD-1 protein / pediatric tumors / Physiology / Tumor microenvironment / Tumor Microenvironment - immunology / Tumors