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Synthesis of Extended Uridine Phosphonates Derived from an Allosteric P2Y2 Receptor Ligand
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Synthesis of Extended Uridine Phosphonates Derived from an Allosteric P2Y2 Receptor Ligand
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Journal Article
Synthesis of Extended Uridine Phosphonates Derived from an Allosteric P2Y2 Receptor Ligand
2014
Overview
In this study we report the synthesis of C5/C6-fused uridine phosphonates that are structurally related to earlier reported allosteric P2Y2 receptor ligands. A silyl-Hilbert-Johnson reaction of six quinazoline-2,4-(1H,3H)-dione-like base moieties with a suitable ribofuranosephosphonate afforded the desired analogues after full deprotection. In contrast to the parent 5-(4-fluoropheny)uridine phosphonate, the present extended-base uridine phosphonates essentially failed to modulate the P2Y2 receptor.
Publisher
MDPI AG,MDPI
Subject
/ Humans
/ Ligands
/ Organophosphonates - chemical synthesis
/ Organophosphonates - pharmacology
/ Purinergic P2Y Receptor Agonists - chemical synthesis
/ Purinergic P2Y Receptor Agonists - pharmacology
/ Receptors, Purinergic P2Y2 - metabolism
/ Uridine - analogs & derivatives
