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β2 Integrin CD11d/CD18: From Expression to an Emerging Role in Staged Leukocyte Migration
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β2 Integrin CD11d/CD18: From Expression to an Emerging Role in Staged Leukocyte Migration
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Journal Article
β2 Integrin CD11d/CD18: From Expression to an Emerging Role in Staged Leukocyte Migration
2021
Overview
CD11d/CD18 is the most recently discovered and least understood β2 integrin. Known CD11d adhesive mechanisms contribute to both extravasation and mesenchymal migration – two key aspects for localizing peripheral leukocytes to sites of inflammation. Differential expression of CD11d induces differences in monocyte/macrophage mesenchymal migration including impacts on macrophage sub-set migration. The participation of CD11d/CD18 in leukocyte localization during atherosclerosis and following neurotrauma has sparked interest in the development of CD11d-targeted therapeutic agents. Whereas the adhesive properties of CD11d have undergone investigation, the signalling pathways induced by ligand binding remain largely undefined. Underlining each adhesive and signalling function, CD11d is under unique transcriptional control and expressed on a sub-set of predominately tissue-differentiated innate leukocytes. The following review is the first to capture the nearly three decades of CD11d research and discusses the emerging role of CD11d in leukocyte migration and retention during the progression of a staged immune response.
Publisher
Frontiers Media SA,Frontiers Media S.A
Subject
/ CD11d
/ CD18
/ Chemotaxis, Leukocyte - genetics
/ Chemotaxis, Leukocyte - immunology
/ Genes
/ Humans
/ Integrin alpha Chains - chemistry
/ Integrin alpha Chains - genetics
/ Integrin alpha Chains - metabolism
/ Ligands
/ Organ Specificity - genetics
/ Peptides
/ Protein Interaction Domains and Motifs
/ Protein Processing, Post-Translational
/ Structure-Activity Relationship
/ Trauma
