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Effects of medication on dopamine transporter imaging using 123II-FP-CIT SPECT in routine practice
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Effects of medication on dopamine transporter imaging using 123II-FP-CIT SPECT in routine practice
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Journal Article
Effects of medication on dopamine transporter imaging using 123II-FP-CIT SPECT in routine practice
2024
Overview
Purpose
Dopamine transporter (DAT) imaging is used to support the diagnosis of neurodegenerative parkinsonian disorders. Specific medications have been reported to confound the interpretation of [
123
I]I-FP-CIT SPECT scans, but there is limited data. The aim of the current study is to identify potential medication effects on the interpretation of [
123
I]I-FP-CIT SPECT scans in routine practice.
Materials and methods
Consecutive patients undergoing a [
123
I]I-FP-CIT SPECT/CT scan on a 360° CZT camera between September 2019 and December 2022 were included. An exhaustive review of patient medications (antidepressants, antipsychotics, anti-epileptics, anti-parkinsonians, benzodiazepines, lithium, opioids, and stimulants) was performed. Two experienced nuclear physicians, blinded to the medication reports, interpreted the [
123
I]I-FP-CIT SPECT scans visually and a semi-quantitative analysis was performed using a local normal database.
Results
The study included 305 patients (71.0 ± 10.4, 135 women) and 145 (47.5%) visually interpreted normal scans. In normal scans, the striatum/occiput radioligand uptake ratio was decreased by noradrenergic and specific serotonergic antidepressants (NASSAs) (
n
= 15, z-score of − 0.93) and opioid medication (tramadol,
n
= 6, z-score of − 0.85) and was associated with a younger age in the multivariate analysis. In the overall population, the striatum/occiput ratio was influenced by NASSAs and associated with consensual visual analysis, age, sex, and anti-parkinsonian medications related to the status of the disease.
Conclusion
Our study confirms the potential impact of antidepressant (NASSA) and opioid (tramadol) medications on the semi-quantitative analysis of [
123
I]I-FP-CIT SPECT scans. However, when performing a visual analysis, only NASSAs significantly impacted the interpretation of [
123
I]I-FP-CIT SPECT scans.
Publisher
Springer Berlin Heidelberg,Springer Nature B.V
Subject
