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Bifidobacteria adolescentis regulated immune responses and gut microbial composition to alleviate DNFB-induced atopic dermatitis in mice
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Bifidobacteria adolescentis regulated immune responses and gut microbial composition to alleviate DNFB-induced atopic dermatitis in mice
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Journal Article
Bifidobacteria adolescentis regulated immune responses and gut microbial composition to alleviate DNFB-induced atopic dermatitis in mice
2020
Overview
Purpose
Emerging studies have reported gut microbial composition plays a key role in alleviating AD clinical symptoms during the probiotic intervention, but the correlation among clinical symptoms, immune responses and gut microbial alteration needs to be explored. Therefore, the objective was to investigate the correlation during
Bifidobacterium adolescentis
intervention in DNFB-induced AD mice.
Methods
The mice were randomly divided into nine groups and fed
B. adolescentis
for 3 weeks. At the end of the experiment, clinical and immune indicators were assessed. Flow cytometry was performed to explore the effect of
B. adolescentis
on regulatory T cells in the spleen. V3–V4 region of the 16S ribosomal RNA (rRNA) gene was sequenced to evaluate changes in the gut microbiota.
Results
Bifidobacteria adolescentis
treatments reduced ear and skin thickness and suppressed eosinophils and mast cells infiltration. Th1- and Th2-type responses were regulated and the Tregs population was promoted in the spleen by
B. adolescentis
treatments.
Bifidobacteria adolescentis
increased the relative abundance of
Lactobacillus
but decrease
Dorea
and
Pediococcus
. Propionic and butyric acids were increased but isovaleric acid was decreased by
B. adolescentis
treatment. Besides, the functional modules, such as fatty acid biosynthesis, antigen processing and presentation were upregulated by
B. adolescentis
Ad1 treatment compared to the DNFB group.
Conclusion
Collectively, these results imply that
B. adolescentis
with the role of immunomodulation promotes Treg differentiation and suppresses Th2 responses, and increases the proportion of
Lactobacillus
that is positively correlated to increase in propionic acid production, and thus has the potential for AD amelioration.
Publisher
Springer Berlin Heidelberg,Springer Nature B.V
Subject
/ Antigens
/ Bifidobacterium adolescentis
/ Chemistry and Materials Science
/ ears
/ Eczema
/ Feces
/ genes
/ rRNA 16S
/ Spleen
