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Pulmonary Complications in Hematopoietic Stem Cell Transplant Recipients—A Clinician Primer

by Joshua, Jisha , Mandel, Jess , Jamieson, Catriona , Nokes, Brandon , Astashchanka, Anna , Ryan, Joseph , Kligerman, Seth , Lin, Erica , Malhotra, Atul

in Antibiotics / Antifungal agents / Blood / Blood platelets / Bone marrow / Chemotherapy / Clinical medicine / Fever / Graft versus host disease / Hemorrhage / Mortality / Neutrophils / Patients / Pneumonia / Radiation / Respiratory distress syndrome / Review / Stem cell transplantation / Ventilators

2021

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Pulmonary Complications in Hematopoietic Stem Cell Transplant Recipients—A Clinician Primer

by Joshua, Jisha , Mandel, Jess , Jamieson, Catriona , Nokes, Brandon , Astashchanka, Anna , Ryan, Joseph , Kligerman, Seth , Lin, Erica , Malhotra, Atul

2021

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Pulmonary Complications in Hematopoietic Stem Cell Transplant Recipients—A Clinician Primer

by Joshua, Jisha , Mandel, Jess , Jamieson, Catriona , Nokes, Brandon , Astashchanka, Anna , Ryan, Joseph , Kligerman, Seth , Lin, Erica , Malhotra, Atul

2021

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Journal Article

Pulmonary Complications in Hematopoietic Stem Cell Transplant Recipients—A Clinician Primer

Joshua, Jisha,

Mandel, Jess,

Jamieson, Catriona,

Nokes, Brandon,

Astashchanka, Anna,

Ryan, Joseph,

Kligerman, Seth,

Lin, Erica,

Malhotra, Atul

2021

Overview

Hematopoietic stem cell transplants (HSCT) are becoming more widespread as a result of optimization of conditioning regimens and prevention of short-term complications with prophylactic antibiotics and antifungals. However, pulmonary complications post-HSCT remain a leading cause of morbidity and mortality and are a challenge to clinicians in both diagnosis and treatment. This comprehensive review provides a primer for non-pulmonary healthcare providers, synthesizing the current evidence behind common infectious and non-infectious post-transplant pulmonary complications based on time (peri-engraftment, early post-transplantation, and late post-transplantation). Utilizing the combination of timing of presentation, clinical symptoms, histopathology, and radiographic findings should increase rates of early diagnosis, treatment, and prognostication of these severe illness states.

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Publisher

MDPI AG,MDPI

Subject

/ Blood