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Lipid-polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives
by
Kalyan, Pranav
, Yenugonda, Venkata Mahidhar
, Waters, Ariana K
, Achrol, Achal Singh
, Kesari, Santosh
, Mukherjee, Anubhab
in
Animals
/ Cancer therapies
/ Drug Delivery
/ Drug Delivery Systems - methods
/ FDA approval
/ Gene Delivery
/ Humans
/ Lipid Based Nanoparticle
/ Lipid Polymer Hybrid Nanopartcle
/ lipid-polymer hybrid nanoparticle
/ Lipids
/ Lipids - administration & dosage
/ Lipids - chemistry
/ Liposomes - administration & dosage
/ Liposomes - chemistry
/ Nanoparticles - administration & dosage
/ Nanoparticles - chemistry
/ Nanotechnology - methods
/ Polyethylene glycol
/ Polymer Based Nanopartcles
/ polymer-based nanoparticles
/ Polymers - administration & dosage
/ Polymers - chemistry
/ Review
2019
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Lipid-polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives
by
Kalyan, Pranav
, Yenugonda, Venkata Mahidhar
, Waters, Ariana K
, Achrol, Achal Singh
, Kesari, Santosh
, Mukherjee, Anubhab
in
Animals
/ Cancer therapies
/ Drug Delivery
/ Drug Delivery Systems - methods
/ FDA approval
/ Gene Delivery
/ Humans
/ Lipid Based Nanoparticle
/ Lipid Polymer Hybrid Nanopartcle
/ lipid-polymer hybrid nanoparticle
/ Lipids
/ Lipids - administration & dosage
/ Lipids - chemistry
/ Liposomes - administration & dosage
/ Liposomes - chemistry
/ Nanoparticles - administration & dosage
/ Nanoparticles - chemistry
/ Nanotechnology - methods
/ Polyethylene glycol
/ Polymer Based Nanopartcles
/ polymer-based nanoparticles
/ Polymers - administration & dosage
/ Polymers - chemistry
/ Review
2019
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Lipid-polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives
by
Kalyan, Pranav
, Yenugonda, Venkata Mahidhar
, Waters, Ariana K
, Achrol, Achal Singh
, Kesari, Santosh
, Mukherjee, Anubhab
in
Animals
/ Cancer therapies
/ Drug Delivery
/ Drug Delivery Systems - methods
/ FDA approval
/ Gene Delivery
/ Humans
/ Lipid Based Nanoparticle
/ Lipid Polymer Hybrid Nanopartcle
/ lipid-polymer hybrid nanoparticle
/ Lipids
/ Lipids - administration & dosage
/ Lipids - chemistry
/ Liposomes - administration & dosage
/ Liposomes - chemistry
/ Nanoparticles - administration & dosage
/ Nanoparticles - chemistry
/ Nanotechnology - methods
/ Polyethylene glycol
/ Polymer Based Nanopartcles
/ polymer-based nanoparticles
/ Polymers - administration & dosage
/ Polymers - chemistry
/ Review
2019
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Lipid-polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives
Journal Article
Lipid-polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives
2019
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Overview
Lipid-polymer hybrid nanoparticles (LPHNPs) are next-generation core-shell nanostructures, conceptually derived from both liposome and polymeric nanoparticles (NPs), where a polymer core remains enveloped by a lipid layer. Although they have garnered significant interest, they remain not yet widely exploited or ubiquitous. Recently, a fundamental transformation has occurred in the preparation of LPHNPs, characterized by a transition from a two-step to a one-step strategy, involving synchronous self-assembly of polymers and lipids. Owing to its two-in-one structure, this approach is of particular interest as a combinatorial drug delivery platform in oncology. In particular, the outer surface can be decorated in multifarious ways for active targeting of anticancer therapy, delivery of DNA or RNA materials, and use as a diagnostic imaging agent. This review will provide an update on recent key advancements in design, synthesis, and bioactivity evaluation as well as discussion of future clinical possibilities of LPHNPs.
Publisher
Taylor & Francis Ltd,Dove Press,Dove Medical Press
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