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Antiproliferative Potential of Cobalt(II) Phenanthroline Complexes with Pyridonates
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Antiproliferative Potential of Cobalt(II) Phenanthroline Complexes with Pyridonates
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Journal Article
Antiproliferative Potential of Cobalt(II) Phenanthroline Complexes with Pyridonates
2025
Overview
The reaction of CoCl2 · 6H2O with 6-chloro-2-hydroxypyridine (Hchp) and 1,10-phenanthroline (phen) afforded the complex [Co(chp)2(phen)] (1). Although this complex has been previously reported, it was obtained in this work under mild conditions (in acetonitrile at room temperature) and characterized for the first time by single-crystal X-ray diffraction. The use of Co(F3CCOO)2 · 4H2O under similar conditions yielded a new trinuclear molecular complex [Co3(chp)2(F3CCOO)4(phen)2] (2). According to X-ray diffraction data, the cobalt(II) ions in complexes 1 and 2 are located in an octahedral environment (coordination number CNCo = 6). As an ambidentate ligand, Hchp exhibits different types of coordination modes in the resulting complexes 1 and 2. Additional stabilization of molecules in the crystal is achieved by π-π stacking between aromatic systems of coordinated phen ligands. The cytotoxic activity of 1 and [CoCl2(phen)2] · 1.5MeCN (3) against a panel of human cancer cell lines (SKBR3, HCT116, A549) and normal dermal fibroblasts (HDF) was evaluated using the MTT assay. Complex 3 demonstrated cytotoxic activity against the HCT116 cell line comparable to that of cisplatin, indicating its potential as a promising antitumor agent.
Publisher
MDPI AG
Subject
/ Antineoplastic Agents - chemical synthesis
/ Antineoplastic Agents - chemistry
/ Antineoplastic Agents - pharmacology
/ Cancer
/ Cell Proliferation - drug effects
/ Chloride
/ Cobalt
/ Coordination Complexes - chemical synthesis
/ Coordination Complexes - chemistry
/ Coordination Complexes - pharmacology
/ Drug Screening Assays, Antitumor
/ Humans
/ Ligands
/ Metals
/ Phenanthrolines - pharmacology
/ X-rays
