Journal Article

The existence of Aβ strains and their potential for driving phenotypic heterogeneity in Alzheimer’s disease

Lau, Heather H, Ingelsson, Martin, Watts, Joel C

2021

Overview

Reminiscent of the human prion diseases, there is considerable clinical and pathological variability in Alzheimer’s disease, the most common human neurodegenerative condition. As in prion disorders, protein misfolding and aggregation is a hallmark feature of Alzheimer’s disease, where the initiating event is thought to be the self-assembly of Aβ peptide into aggregates that deposit in the central nervous system. Emerging evidence suggests that Aβ, similar to the prion protein, can polymerize into a conformationally diverse spectrum of aggregate strains both in vitro and within the brain. Moreover, certain types of Aβ aggregates exhibit key hallmarks of prion strains including divergent biochemical attributes and the ability to induce distinct pathological phenotypes when intracerebrally injected into mouse models. In this review, we discuss the evidence demonstrating that Aβ can assemble into distinct strains of aggregates and how such strains may be primary drivers of the phenotypic heterogeneity in Alzheimer’s disease.

• Publisher: Springer Nature B.V
• Subject: Alzheimer's disease / Animal models / Central nervous system / Neurodegenerative diseases / Phenotypes / Prion protein / Protein folding / Self-assembly