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High Mobility Group Box-1 and Diabetes Mellitus Complications: State of the Art and Future Perspectives
by
Biscetti, Federico
, Rando, Maria Margherita
, Landolfi, Raffaele
, Pecorini, Giovanni
, Cecchini, Andrea Leonardo
, Flex, Andrea
, Nardella, Elisabetta
in
Angiogenesis
/ Animals
/ Atherosclerosis
/ Chronic illnesses
/ Cytokines
/ Cytoplasm
/ Diabetes
/ Diabetes Complications - metabolism
/ Disease
/ Glucose
/ HMGB1 Protein - metabolism
/ Humans
/ Hyperglycemia
/ Inflammation
/ Insulin resistance
/ Kinases
/ Metabolism
/ Models, Biological
/ Oxidative stress
/ Pathogenesis
/ Proteins
/ Review
2019
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High Mobility Group Box-1 and Diabetes Mellitus Complications: State of the Art and Future Perspectives
by
Biscetti, Federico
, Rando, Maria Margherita
, Landolfi, Raffaele
, Pecorini, Giovanni
, Cecchini, Andrea Leonardo
, Flex, Andrea
, Nardella, Elisabetta
in
Angiogenesis
/ Animals
/ Atherosclerosis
/ Chronic illnesses
/ Cytokines
/ Cytoplasm
/ Diabetes
/ Diabetes Complications - metabolism
/ Disease
/ Glucose
/ HMGB1 Protein - metabolism
/ Humans
/ Hyperglycemia
/ Inflammation
/ Insulin resistance
/ Kinases
/ Metabolism
/ Models, Biological
/ Oxidative stress
/ Pathogenesis
/ Proteins
/ Review
2019
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High Mobility Group Box-1 and Diabetes Mellitus Complications: State of the Art and Future Perspectives
by
Biscetti, Federico
, Rando, Maria Margherita
, Landolfi, Raffaele
, Pecorini, Giovanni
, Cecchini, Andrea Leonardo
, Flex, Andrea
, Nardella, Elisabetta
in
Angiogenesis
/ Animals
/ Atherosclerosis
/ Chronic illnesses
/ Cytokines
/ Cytoplasm
/ Diabetes
/ Diabetes Complications - metabolism
/ Disease
/ Glucose
/ HMGB1 Protein - metabolism
/ Humans
/ Hyperglycemia
/ Inflammation
/ Insulin resistance
/ Kinases
/ Metabolism
/ Models, Biological
/ Oxidative stress
/ Pathogenesis
/ Proteins
/ Review
2019
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High Mobility Group Box-1 and Diabetes Mellitus Complications: State of the Art and Future Perspectives
Journal Article
High Mobility Group Box-1 and Diabetes Mellitus Complications: State of the Art and Future Perspectives
2019
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Overview
Diabetes mellitus (DM) is an endemic disease, with growing health and social costs. The complications of diabetes can affect potentially all parts of the human body, from the heart to the kidneys, peripheral and central nervous system, and the vascular bed. Although many mechanisms have been studied, not all players responsible for these complications have been defined yet. High Mobility Group Box-1 (HMGB1) is a non-histone nuclear protein that has been implicated in many pathological processes, from sepsis to ischemia. The purpose of this review is to take stock of all the most recent data available on the role of HMGB1 in the complications of DM.
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