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The Anti-Inflammatory Properties of Licorice (Glycyrrhiza glabra)-Derived Compounds in Intestinal Disorders

by Bonafé, Gabriel Alves , Ribeiro, Marcelo Lima , Martinez, Carlos Augusto Real , Leite, Camila dos Santos , Ortega, Manoela Marques , Carvalho Santos, Juliana

in Anti-Inflammatory Agents - therapeutic use / Antioxidants / Antiviral drugs / Apoptosis / Cell growth / Colorectal cancer / Cytochrome / Cytokines / Disease / Enzymes / Gastric cancer / Glycyrrhiza / Hepatitis / Humans / Inflammation / Inflammatory bowel disease / Inflammatory Bowel Diseases - drug therapy / Kinases / Leukemia / Lipid peroxidation / Liver / Nitric oxide / Oxidative stress / Permeability / Plant Extracts - pharmacology / Polyethylene glycol / Prostate cancer / Proteins / Review / Traditional Chinese medicine / Triterpenes - pharmacology

2022

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The Anti-Inflammatory Properties of Licorice (Glycyrrhiza glabra)-Derived Compounds in Intestinal Disorders

by Bonafé, Gabriel Alves , Ribeiro, Marcelo Lima , Martinez, Carlos Augusto Real , Leite, Camila dos Santos , Ortega, Manoela Marques , Carvalho Santos, Juliana

2022

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The Anti-Inflammatory Properties of Licorice (Glycyrrhiza glabra)-Derived Compounds in Intestinal Disorders

by Bonafé, Gabriel Alves , Ribeiro, Marcelo Lima , Martinez, Carlos Augusto Real , Leite, Camila dos Santos , Ortega, Manoela Marques , Carvalho Santos, Juliana

2022

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Journal Article

The Anti-Inflammatory Properties of Licorice (Glycyrrhiza glabra)-Derived Compounds in Intestinal Disorders

Bonafé, Gabriel Alves,

Ribeiro, Marcelo Lima,

Martinez, Carlos Augusto Real,

Leite, Camila dos Santos,

Ortega, Manoela Marques,

Carvalho Santos, Juliana

2022

Overview

Intestinal diseases, such as inflammatory bowel diseases (IBDs) and colorectal cancer (CRC), are a significant source of morbidity and mortality worldwide. Epidemiological data have shown that IBD patients are at an increased risk for the development of CRC. IBD-associated cancer develops against a background of chronic inflammation and oxidative stress, and their products contribute to cancer development and progression. Therefore, the discovery of novel drugs for the treatment of intestinal diseases is urgently needed. Licorice (Glycyrrhiza glabra) has been largely used for thousands of years in traditional Chinese medicine. Licorice and its derived compounds possess antiallergic, antibacterial, antiviral, anti-inflammatory, and antitumor effects. These pharmacological properties aid in the treatment of inflammatory diseases. In this review, we discuss the pharmacological potential of bioactive compounds derived from Licorice and addresses their anti-inflammatory and antioxidant properties. We also discuss how the mechanisms of action in these compounds can influence their effectiveness and lead to therapeutic effects on intestinal disorders.

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Publisher

MDPI AG,MDPI

Subject

Anti-Inflammatory Agents - therapeutic use