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Manipulation of Autophagy by Bacterial Pathogens Impacts Host Immunity
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Manipulation of Autophagy by Bacterial Pathogens Impacts Host Immunity
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Book Chapter
Manipulation of Autophagy by Bacterial Pathogens Impacts Host Immunity
2018
Overview
Autophagy is a highly conserved catabolic process, degrading unnecessary or damaged components in the eukaryotic cell to maintain cellular homeostasis, but it is also an intrinsic cellular defence mechanism to remove invading pathogens. A crosstalk between autophagy and innate or adaptive immune responses has been recently reported, whereby autophagy influences both, innate and adaptive immunity like the production and secretion of pro-inflammatory cytokines or MHC class II antigen presentation to T cells. Pathogenic bacteria have evolved diverse strategies to manipulate autophagy, mechanisms that also impact host immune responses at different levels. Here we discuss the influence of autophagy on self-autonomous, innate and adaptive immunity and then focus on how bacterial mechanisms that shape autophagy may impact the host immune system.
Publisher
Caister Academic Press
Subject
/ Animals
/ Autophagosomes / microbiology
/ Gram-Negative Bacteria / growth & development
/ Gram-Negative Bacteria / immunology
/ Gram-Positive Bacteria / growth & development
/ Gram-Positive Bacteria / immunology
/ Histocompatibility Antigens Class II / genetics
/ Histocompatibility Antigens Class II / immunology
/ Humans
/ Microbiology and Parasitology
/ T-Lymphocytes / microbiology
ISBN
9781910190692, 1910190691
