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Evaluation of white matter microstructure in patients with Parkinson’s disease using microscopic fractional anisotropy
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Evaluation of white matter microstructure in patients with Parkinson’s disease using microscopic fractional anisotropy
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Evaluation of white matter microstructure in patients with Parkinson’s disease using microscopic fractional anisotropy
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Journal Article
Evaluation of white matter microstructure in patients with Parkinson’s disease using microscopic fractional anisotropy
2020
Overview
Purpose
Micro fractional anisotropy (μFA) is more accurate than conventional fractional anisotropy (FA) for assessing microscopic tissue properties and can overcome limitations related to crossing white matter fibres. We compared μFA and FA for evaluating white matter changes in patients with Parkinson’s disease (PD).
Methods
We compared FA and μFA measures between 25 patients with PD and 25 age- and gender-matched healthy controls using tract-based spatial statistics (TBSS) analysis. We also examined potential correlations between changes, revealed by conventional FA or μFA, and disease duration or Unified Parkinson’s Disease Rating Scale (UPDRS)-III scores.
Results
Compared with healthy controls, patients with PD had significantly reduced μFA values, mainly in the anterior corona radiata (ACR). In the PD group, μFA values (primarily those from the ACR) were significantly negatively correlated with UPDRS-III motor scores. No significant changes or correlations with disease duration or UPDRS-III scores with tissue properties were detected using conventional FA.
Conclusion
μFA can evaluate microstructural changes that occur during white matter degeneration in patients with PD and may overcome a key limitation of FA.
