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The first enantioselective total synthesis of（＋）-preussin B and an improved synthesis of（＋）-preussin by step-economical methods
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The first enantioselective total synthesis of（＋）-preussin B and an improved synthesis of（＋）-preussin by step-economical methods
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Journal Article
The first enantioselective total synthesis of（＋）-preussin B and an improved synthesis of（＋）-preussin by step-economical methods
2015
Overview
The first enantioselective total synthesis of（＋）-preussin B and an improved synthesis of the antifungal alkaloid（＋）-preussin are described. Our approach relied on the four step-economical synthetic methods developed in our laboratory：（1） the cis-diastereoselective reductive dehydroxylation of hemiaminals;（2） the direct amide/lactam reductive alkylation;（3） the one-pot N,O-bisdebenzylation-N-methylation; and（4） the one-step synthesis of malimide from malic acid. Both total syntheses are quite concise, which have been achieved in six steps, and gave overall yields of 25.7% and 27.6%, respectively.
