Asset Details
Do you wish to reserve the book?
CD3+/CD19+-depleted grafts in HLA-matched allogeneic peripheral blood stem cell transplantation lead to early NK cell cytolytic responses and reduced inhibitory activity of NKG2A
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
CD3+/CD19+-depleted grafts in HLA-matched allogeneic peripheral blood stem cell transplantation lead to early NK cell cytolytic responses and reduced inhibitory activity of NKG2A
Do you wish to request the book?
CD3+/CD19+-depleted grafts in HLA-matched allogeneic peripheral blood stem cell transplantation lead to early NK cell cytolytic responses and reduced inhibitory activity of NKG2A
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
CD3+/CD19+-depleted grafts in HLA-matched allogeneic peripheral blood stem cell transplantation lead to early NK cell cytolytic responses and reduced inhibitory activity of NKG2A
2010
Overview
Natural killer (NK) cells have an important function in the anti-tumor response early after stem cell transplantation (SCT). As part of a prospective randomized phase III study, directly comparing the use of CD3
+
/CD19
+
-depleted peripheral blood stem cell (PBSC) harvests with CD34
+
-selected PBSC harvests in allogeneic human leukocyte antigen-matched SCT, we here show that the use of CD3
+
/CD19
+
-depleted PBSC grafts leads to early NK cell repopulation and reconstitution of the CD56
dim
and CD56
bright
NK cell subsets, with concomitant high cytolytic capacity. In the CD34 group, this process took significantly longer. Moreover, in the CD3/19 group after reconstitution, a higher percentage of killer immunoglobulin-like receptor-positive NK cells was found. Although similar percentages of CD94-positive NK cells were found in both groups, in the CD34 group, almost all expressed the inhibitory CD94:NKG2A complex, whereas in the CD3/19 group, the inhibitory CD94:NKG2A and the activating CD94:NKG2C complex were equally distributed. This preferential development of NKG2C-expressing NK cells in the CD3/19 group was paralleled by a loss of NKG2A-mediated inhibition of NK cell degranulation. These results show that the use of CD3
+
/CD19
+
-depleted grafts facilitates strong NK cell cytolytic responses directly after SCT, and the rapid emergence of an NK cell receptor phenotype that is more prone to activation.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Aged
/ Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
/ Antigens
/ Biological and medical sciences
/ Blood
/ Bone marrow, stem cells transplantation. Graft versus host reaction
/ Grafting
/ Hematologic and hematopoietic diseases
/ Histocompatibility antigen HLA
/ Humans
/ Killer Cells, Natural - immunology
/ Medicine
/ NK Cell Lectin-Like Receptor Subfamily C - physiology
/ NK Cell Lectin-Like Receptor Subfamily D - analysis
/ Oncology
/ Peripheral Blood Stem Cell Transplantation
/ Transfusions. Complications. Transfusion reactions. Cell and gene therapy
/ Tumors
