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The Effect of Organoselenium Compounds on Histone Deacetylase Inhibition and Their Potential for Cancer Therapy
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The Effect of Organoselenium Compounds on Histone Deacetylase Inhibition and Their Potential for Cancer Therapy
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Journal Article
The Effect of Organoselenium Compounds on Histone Deacetylase Inhibition and Their Potential for Cancer Therapy
2021
Overview
Genetic and epigenetic changes alter gene expression, contributing to cancer. Epigenetic changes in cancer arise from alterations in DNA and histone modifications that lead to tumour suppressor gene silencing and the activation of oncogenes. The acetylation status of histones and non-histone proteins are determined by the histone deacetylases and histone acetyltransferases that control gene transcription. Organoselenium compounds have become promising contenders in cancer therapeutics. Apart from their anti-oxidative effects, several natural and synthetic organoselenium compounds and metabolites act as histone deacetylase inhibitors, which influence the acetylation status of histones and non-histone proteins, altering gene transcription. This review aims to summarise the effect of natural and synthetic organoselenium compounds on histone and non-histone protein acetylation/deacetylation in cancer therapy.
Publisher
MDPI AG,MDPI
Subject
/ Cancer
/ Epigenesis, Genetic - drug effects
/ Histone Deacetylase Inhibitors - chemical synthesis
/ Histone Deacetylase Inhibitors - metabolism
/ Histone Deacetylase Inhibitors - pharmacology
/ Histone Deacetylases - metabolism
/ Humans
/ Organoselenium Compounds - chemical synthesis
/ Organoselenium Compounds - metabolism
/ Organoselenium Compounds - pharmacology
/ Prostate
/ Protein Processing, Post-Translational - drug effects
/ Proteins
/ Review
/ Selenium
/ Toxicity
