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Peptide YY(3–36) Inhibits Morning, but Not Evening, Food Intake and Decreases Body Weight in Rhesus Macaques
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Peptide YY(3–36) Inhibits Morning, but Not Evening, Food Intake and Decreases Body Weight in Rhesus Macaques
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Journal Article
Peptide YY(3–36) Inhibits Morning, but Not Evening, Food Intake and Decreases Body Weight in Rhesus Macaques
2005
Overview
Peptide YY (3–36) Inhibits Morning, but Not Evening, Food Intake and Decreases Body Weight in Rhesus Macaques
Frank H. Koegler 1 2 ,
Pablo J. Enriori 1 ,
Sonja K. Billes 1 ,
Diana L. Takahashi 2 ,
Meghan S. Martin 2 ,
Randall L. Clark 2 ,
Anne E. Evans 1 ,
Kevin L. Grove 1 ,
Judy L. Cameron 1 2 and
Michael A. Cowley 1
1 Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon
2 Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton,
Oregon
Address correspondence and reprint requests to Michael Cowley, PhD, Oregon National Primate Research Center, Oregon Health
& Science University, 505 NW 185th Ave., Beaverton, OR 97006. E-mail: cowleym{at}ohsu.edu
Abstract
Peptide YY (3–36) [PYY (3–36) ] is a hormone that is released after meal ingestion that is currently being investigated for the treatment of obesity; however,
there are conflicting reports of the effects of PYY (3–36) on energy balance in rodent models. To shed light on this controversy, we studied the effect of PYY (3–36) on food intake and body weight in a nonhuman primate. Intravenous PYY (3–36) infusions before a morning meal transiently suppressed the rate of food intake but did not suppress the evening meal or 24-h
intake. Twice-daily or continuous intravenous PYY (3–36) infusions to supraphysiological levels (levels that exceeded normal physiological levels) again suppressed the rate of feeding
for the morning but not the evening meal. Twice-daily intravenous PYY (3–36) infusions for 2 weeks significantly decreased body weight in all test animals (average weight loss 1.9%) without changing
insulin response to glucose infusion. These results show that endogenous PYY (3–36) may alter morning but not evening meal intake, and supraphysiological doses are required for effective suppression of food
intake.
ARH, arcuate nucleus of the hypothalamus
IVGTT, intravenous glucose tolerance test
NPY, neuropeptide Y
ONPRC, Oregon National Primate Research Center
PYY(3–36), peptide YY(3–36)
Footnotes
Accepted August 5, 2005.
Received December 28, 2004.
DIABETES
Publisher
American Diabetes Association
Subject
/ Biological and medical sciences
/ Diabetes. Impaired glucose tolerance
/ Drug Administration Schedule
/ Endocrine pancreas. Apud cells (diseases)
/ Etiopathogenesis. Screening. Investigations. Target tissue resistance
/ Feeding Behavior - drug effects
/ Feeding Behavior - physiology
/ Male
