Asset Details
Do you wish to reserve the book?
Synthesis, Characterization, HSA/DNA Binding, and Cytotoxic Activity of RuCl2(η6-p-cymene)(bph-κN) Complex
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Synthesis, Characterization, HSA/DNA Binding, and Cytotoxic Activity of RuCl2(η6-p-cymene)(bph-κN) Complex
Do you wish to request the book?
Synthesis, Characterization, HSA/DNA Binding, and Cytotoxic Activity of RuCl2(η6-p-cymene)(bph-κN) Complex
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Synthesis, Characterization, HSA/DNA Binding, and Cytotoxic Activity of RuCl2(η6-p-cymene)(bph-κN) Complex
2025
Overview
A novel ruthenium(II) complex, [RuCl2(η6-p-cymene)(bph-κN)] (1), was synthesized and structurally characterized using FTIR and NMR spectroscopy. Density functional theory (DFT) calculations supported the proposed geometry and allowed for comparative analysis of experimental and theoretical spectroscopic data. The interaction of complex 1 with human serum albumin (HSA) and calf thymus DNA was investigated through fluorescence quenching experiments, revealing spontaneous binding driven primarily by hydrophobic interactions. The thermodynamic parameters indicated mixed quenching mechanisms in both protein and DNA systems. Ethidium bromide displacement assays and molecular docking simulations confirmed DNA intercalation as the dominant binding mode, with a Gibbs free binding energy of −34.1 kJ mol−1. Antioxidant activity, assessed by EPR spectroscopy, demonstrated effective scavenging of hydroxyl and ascorbyl radicals. In vitro cytotoxicity assays against A375, MDA-MB-231, MIA PaCa-2, and SW480 cancer cell lines revealed selective activity, with pancreatic and colorectal cells showing the highest sensitivity. QTAIM analysis provided insight into metal–ligand bonding characteristics and intramolecular stabilization. These findings highlight the potential of 1 as a promising candidate for further development as an anticancer agent, particularly against multidrug-resistant tumors.
Publisher
MDPI AG,MDPI
Subject
/ Antineoplastic Agents - chemical synthesis
/ Antineoplastic Agents - chemistry
/ Antineoplastic Agents - pharmacology
/ Antioxidants - chemical synthesis
/ Cattle
/ Coordination Complexes - chemical synthesis
/ Coordination Complexes - chemistry
/ Coordination Complexes - pharmacology
/ DFT
/ DNA
/ EPR
/ HSA
/ Humans
/ Ligands
/ Molecular Docking Simulation
/ Serum Albumin, Human - chemistry
/ Serum Albumin, Human - metabolism
/ Toxicity
/ Tumors
