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Firefighting Induces Acute Inflammatory Responses that are not Relieved by Aspirin in Older Firefighters
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Firefighting Induces Acute Inflammatory Responses that are not Relieved by Aspirin in Older Firefighters
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Journal Article
Firefighting Induces Acute Inflammatory Responses that are not Relieved by Aspirin in Older Firefighters
2019
Overview
OBJECTIVE:Sudden cardiac events account for 40% to 50% of firefighter line-of-duty deaths. Inflammatory proteins are strong biomarkers of cardiovascular inflammation. The present study investigated the effects of aspirin supplementation on inflammatory biomarkers following firefighting.
METHODS:Using a randomized, placebo-controlled, double-blind crossover design, 24 male firefighters (48.2 ± 5.9 years) were allocated into four conditionsacute (81 mg; single-dose) aspirin and placebo supplementation, and chronic (81 mg; 14 days) aspirin and placebo supplementation. Inflammatory proteins [interleukin (IL)-6, C-reactive protein (CRP), intracellular adhesion molecule (ICAM)-1, P-selectin, matrix metalloproteinase-9 (MMP-9)] and antioxidant potential [total antioxidant capacity (TAC)] were measured pre- and post-structural firefighting drills.
RESULTS:Firefighting activities significantly increased IL-6, MMP-9, and P-Selectin; however, no changes in TAC and ICAM-1 were detected. Neither acute nor chronic aspirin supplementation attenuated this inflammatory response.
CONCLUSION:Firefighting significantly increases inflammatory biomarkers and neither acute nor chronic low-dose aspirin mitigates this response.
Publisher
Copyright by the American College of Occupational and Environmental Medicine,Lippincott Williams & Wilkins Ovid Technologies
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