Journal Article

Type III protein secretion systems in plant and animal pathogenic bacteria

He, S.Y. (Michigan State University, East Lansing, MI.)

1998

Overview

▪ Abstract  Among many interesting and sophisticated mechanisms used by bacterial pathogens to subvert eukaryotic hosts is a class of specialized protein secretion systems (known as type III protein secretion systems) that deliver bacterial virulence proteins directly into the host cell. Recent studies have revealed four important features of these secretion systems. First, they are widespread among plant and animal bacterial pathogens, and mutations affecting type III protein secretion often eliminate bacterial virulence completely. Second, at least eight type III secretion components share sequence similarities with those of the flagellar assembly machinery and flagellum-like structures are associated with type III secretion, raising the possibility that these secretion systems are derived from the presumably more ancient flagellar assembly apparatus. Third, type III secretion is activated in vivo upon contact with host cells. Fourth, the type III secretion mechanism is Sec-independent and the effector proteins may possess mRNA-based targeting signals. This review highlights the similarities and differences among type III secretion systems of selected model plant and animal pathogenic bacteria.

• Publisher: Annual Reviews,Annual Reviews, Inc
• Subject: AGENT PATHOGENE / AMINO ACID SEQUENCES / animal pathology / BACTERIA / Bacterial plant pathogens / BACTERIAL PROTEINS / Bacteriology / BACTERIOSE / BACTERIOSES / BACTERIOSIS / Biological and medical sciences / CELL STRUCTURE / CHEMICAL COMPOSITION / COMPOSICION QUIMICA / COMPOSITION CHIMIQUE / ENFERMEDADES DE LAS PLANTAS / ESTRUCTURA CELULAR / EXPRESION GENICA / EXPRESSION DES GENES / FLAGELLA / flagellum / Fundamental and applied biological sciences. Psychology / GENE EXPRESSION / GENETIC REGULATION / GENETICA / GENETICS / GENETIQUE / host plants / HOSTS / HOTE / HUESPEDES / LITERATURE REVIEWS / MALADIE DES PLANTES / METABOLISME DES PROTEINES / METABOLISMO PROTEICO / MICROBIAL PROTEINS / Microbiology / MUTACION / MUTATION / NUCLEOTIDE SEQUENCE / nucleotide sequences / ORGANISMOS PATOGENOS / PATHOGENICITY / Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains / PATHOGENS / PATHOLOGIE / PATHOLOGY / PATOGENICIDAD / PATOLOGIA / Phytopathology. Animal pests. Plant and forest protection / PLANT DISEASES / plant diseases and disorders / plant pathogenic bacteria / POUVOIR PATHOGENE / PROTEIN METABOLISM / PROTEIN TRANSPORT / PROTEINAS MICROBIANAS / PROTEINE MICROBIENNE / SECRECION / SECRETION / SECUENCIA NUCLEOTIDICA / SEQUENCE NUCLEOTIDIQUE / STRUCTURE CELLULAIRE / Systematics. Structure, properties and multiplication. Genetics / VIRULENCE